Aminophylline Inhibitor CAS No. 317-34-0

Cat. No.	Name	Size	Price	Add Cart
KI0958	Aminophylline	25 mg	$152
KI0958	Aminophylline	200 mg	$856

Chemical Characteristic

Product Name	Aminophylline
Synonyms	Somopphyllin, Aminocadol, Phyllocontin
CAS No.	317-34-0
Molecular Weight	420.43
Formula	C₁₆H₂₄N₁₀O₄
Chemical Structure

Biological activities

Aminophylline is a bronchodilator. Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole.^[1] Aminophylline also acts by raising the cytoplasmic Ca²⁺ concentration, thereby influencing the PTE-stimulated Ca²⁺ transport mechanism.^[2] Aminophylline inhibits the contractions induced in rat isolated aorta by high K and noradrenaline (NA) as well as the transient contraction induced by NA in Ca²⁺-free media and suppresses the spontaneous myogenic activity in portal vein segments.^[3] Aminophylline preferentially inhibits chloroethylclonidine-insensitive alpha-adrenoceptor-mediated contractions in rat aorta.^[4] In the liver of the rat, aminophylline administration causes an increase in the cyclic AMP level and an elevation in the activity of cyclic AMP-dependent protein kinase.^[5]

Protocols

In vivo: Aminophylline is dissolved in distilled water.^[5]

References

[1] Mader TJ, et al. A randomized controlled trial of intravenous aminophylline for atropine-resistant out-of-hospital asystolic cardiac arrest. Acad Emerg Med. 2003, 10(3): 192-197. 閵嗏偓閵嗏偓 [2] Herrmann-Erlee MP, et al. The effects of dibutyryl cyclic AMP, aminophylline and propranolol on PTE-induced bone resorption in vitro. Endocrinology. 1974, 94(2): 424-434. 閵嗏偓閵嗏偓 [3] Duarte J, et al. Effects of aminophylline on contractions and 45Ca uptake in isolated rat vascular smooth muscle. Gen Pharmacol. 1992, 23(4): 601-606. 閵嗏偓閵嗏偓 [4] Duarte J, et al. Aminophylline preferentially inhibits chloroethylclonidine-insensitive alpha-adrenoceptor-mediated contractions in rat aorta. Gen Pharmacol. 1993, 24(6): 1359-1364. 閵嗏偓閵嗏偓 [5] Costa M, et al. In vivo activation of cAMP-dependent protein kinase by aminophylline and 1-methyl, 3-isobutylxanthine. Biochem Biophys Res Commun. 1975, 65(1): 75-81. 閵嗏偓閵嗏偓

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