Amphotericin b Inhibitor CAS No. 1397-89-3

Cat. No.	Name	Size	Price	Add Cart
KI0912	Amphotericin b	50 mg	$154

Chemical Characteristic

Product Name	Amphotericin b
Synonyms	fungizone
CAS No.	1397-89-3
Molecular Weight	924.08
Formula	C₄₇H₇₃NO₁₇
Chemical Structure

Biological activities

Amphotericin B is an important fungal drug. Amphotericin B remains the drug of choice for treating most systemic mycoses caused by opportunistic fungi.^[1] The MIC of amphotericin B for the C. tropicalis isolate, C. glabrata and the C. krusei isolate are 0.39, 0.2 and 0.78 µg/mL, respectively. ^[2] Amphotericin B is susceptible to C. pseudotropicalis 311, C. albicans 315, C. neoformans 316, C. parapsilosis 356, C. glabrata 359 and C. glabrata B57149^b with IC50 of 7.2, 2.2, 1.0, 6.0, 1.9 and 4.6 µM, respectively. ^[3] In a neutropenic mouse model, amphotericin B produces prolonged dose-dependent suppression of growth after serum levels have fallen below the MIC. ^[4]

Protocols

Amphotericin B solution is prepared by dissolving the stabilized deoxycholate suspension in DMSO to yield a stock solution concentration of 5,000 µg/mL. ^[2]

References

[1] Joly V, et al. In vitro renal toxicity and in vivo therapeutic efficacy in experimental murine cryptococcosis of amphotericin B (Fungizone) associated with Intralipid. Antimicrob Agents Chemother. 1994, 38(2): 177-183. 閵嗏偓閵嗏偓 [2] Fisher MA, et al. Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and Candida krusei. Antimicrob Agents Chemother. 1989, 33(9): 1443-1446. 閵嗏偓閵嗏偓 [3] Helmerhorst EJ, et al. Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides. Antimicrob Agents Chemother. 1999, 43(3): 702-704. 閵嗏偓閵嗏偓 [4] Andes D, et al. Pharmacodynamics of amphotericin B in a neutropenic-mouse disseminated-candidiasis model. Antimicrob Agents Chemother. 2001, 45(3): 922-926. 閵嗏偓閵嗏偓

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