Andarine (GTX-007) Inhibitor CAS No. 401900-40-1

Product Name	Andarine (GTX-007)
Synonyms	GTx-007, S-4
CAS No.	401900-40-1
Molecular Weight	441.36
Formula	C₁₉H₁₈F₃N₃O₆
Chemical Structure
Documents	HNMR COA MS

Biological activities

Andarine is a selective non-steroidal androgen receptor modulator (SARM) with a Ki of 4 nM. Andarine is used for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy. Andarine (10 nM) stimulates AR-mediated transcription to 93%. In castrated male rats, andarine exhibits potent and efficacious anabolic activity and results in dose-dependent stimulation of growth in prostate, seminal vesicles, and levator ani muscle with an ED50 of 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day, respectively.^[1] In the absence of endogenous androgens, andarine acts as an antagonist in the prostate and suppresses prostate growth. Andarine exhibits partial agonist activity in prostate and seminal vesicles of intact and castrated male rats, and full agonist activity in the levator ani muscle.^[2]

Protocols

In vivo, andarine is dissolved in ethanol/PEG300 (5:95, vol/vol).^[2]

References

[1] Yin D, et al. Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther. 2003, 304(3): 1334-1340. [2] Gao W, et al. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology. 2004, 145(12): 5420-5428.

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