Cat. No. Name Size Price Add Cart
KI1050Aniracetam50 mg$112
Aniracetam250 mg$432

Chemical Characteristic

Product NameAniracetam
SynonymsDraganon, Sarpul, Ampamet
CAS No.72432-10-1
Molecular Weight 219.24
FormulaC12H13NO3
Chemical Name1-(4-methoxybenzoyl)pyrrolidin-2-one
SmilesN1(C(=O)CCC1)C(=O)c1ccc(cc1)OC
Chemical Structure

Biological activities

Aniracetam is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. In vitro, treatment of the cultures with aniracetam (1, 10 and 100 mM) during 24 hours ischemia simulated significantly decreases the number of apoptotic rat astrocytes. Aniracetam increases the intracellular ATP and phosphocreatine (PCr) levels and inhibits the caspase-3 activity. Aniracetam also attenuates cellular oxidative stress by decreased production of reactive oxygen species (ROS).[1] Aniracetam potentiates the ionotropic quisqualate (iQA) responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. Aniracetam reversibly potentiates the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices.[2] Aniracetam enhances glutamate-evoked currents in CA1 and CA3 pyramidal whole-cell recordings. Aniracetam strongly reduces glutamate receptor desensitization in outside-out patches. In addition, aniracetam selectively prolongs the time course and increases the peak amplitude of fast synaptic currents.[3]

Protocols

In vivo: Aniracetam is dissolved in DMSO.[2]

References

[1] Gabryel B, et al. Aniracetam attenuates apoptosis of astrocytes subjected to simulated ischemia in vitro. Neurotoxicology. 2002, 23(3): 385-395.
[2] Ito I, et al. Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J Physiol. 1990, 424: 533-543.
[3] Isaacson JS, et al. Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus. Proc Natl Acad Sci U S A. 1991, 88(23): 10936-10940.

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