Cat. No. Name Size Price Add Cart
KI0634Apicidin1 mg$158
Apicidin5 mg$488

Chemical Characteristic

Product NameApicidin
CAS No.183506-66-3
Molecular Weight 623.78
FormulaC34H49N5O6
Chemical NameCyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
SmilesN12C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1CCCC2)CCCCCC(=O)CC)Cc1cn(c2c1cccc2)OC)C(C)CC
Chemical Structure

Biological activities

Apicidin is a potent histone deacetylase (HDAC) inhibitor. Apicidin inhibits HDAC activity in E. tenella homogenates with an IC50 of 0.7 nM.[1] Apicidin is a novel cyclic tetrapeptide with a potent broad spectrum of antiprotozoal activity against apicomplexan parasites. Apicidin is a fungal metabolite shown to exhibit antiparasitic activity. Apicidin shows abroad spectrum of antiproliferative activity against various cancer cell lines (CCD-18Co, HeLa, v-ras-transformed NIH3T3, Colon 3.1-M26, MG63, MCF7, HBL-100, AGS, A2058 and ZR-75-1) with IC50 of 2.36, 0.51, 0.18, 0.17, 1.88, 1.17, 0.57, 0.13, 0.55 and 1.17 µM, respectively. Apicidin induces selective changes in the expression of p21WAF1/Cip1 and gelsolin. [2] Treatment of HL60 cells with apicidin causes a decrease in viable cell number in a dose-dependent manner and an increase in DNA fragmentation, nuclear morphological change, and apoptotic body formation. Apicidin induces apoptosis through selective induction of Fas/Fas ligand. [3] Apicidin induces di- and tri-acetylated forms of histone H4 and the morphological alteration in v-ras-transformed mouse fibroblast NIH3T3 cells. Apicidin strongly inhibits the formation of new vessels on chorioallantoic membrane and the tube formation of ECV304 human vascular endothelial cells. [4] Apicidin has in vivo activity against Plasmodium berghei malaria. [5]

Protocols

Apicidin is dissolved in 100% DMSO. [1]

References

[1] Darkin-Rattray SJ, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996, 93(23): 13143-13147.
[2] Han JW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000, 60(21): 6068-6074.
[3] Kwon SH, et al. Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J Biol Chem. 2002, 277(3): 2073-2080.
[4] Kim SH, et al. Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Biochem Biophys Res Commun. 2004, 315(4): 964-970.
[5] Park JS, et al. A hemorrhagic factor (Apicidin) produced by toxic Fusarium isolates from soybean seeds. Appl Environ Microbiol. 1999, 65(1): 126-130.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.