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Cat. No. Name Size Price Add Cart
KI3733AR-A01441810 mg$164
AR-A01441850 mg$460

Chemical Characteristic

Product NameAR-A014418
CAS No.487021-52-3
Molecular Weight 308.32
FormulaC12H12N4O4S
Chemical NameN-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea
SmilesN(C(=O)Nc1sc(cn1)[N](=O)O)Cc1ccc(cc1)OC
Chemical Structure

Biological activities

AR-A014418 is a selective and effective GSK3? inhibitor with an IC 50 value of 104 +/- 27 nM. It has no significant inhibition on other 26 kinases [1]. AR-A014418 inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in 3T3 fibroblasts expressing human four-repeat tau protein with IC50 of 2.7 ?M, and protects cultured N2A cells from death induced by blocking PI3K/PKB pathway [2]. In vivo, it can be used by 0-4 mg/kg in ALS mouse model. AR-A014418 produces inhibition effect on acetic acid- and formalin-induced nociception in mice by modulating NMDA and metabotropic receptor signaling as well as TNF-? and IL-1? transmission in the spinal cord [3].

References

[1] Bhat R, Xue Y, Berg S, et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem. 2003, 278(46):45937-45945.
[2] Min HJ, Koh SS, Cho IR, Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells. Int J Oncol. 2009, 35(3):617-624. [3] Gould TD, Einat H, Bhat R, AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int J Neuropsychopharmacol. 2004 , 7(4):387-390.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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