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Cat. No. Name Size Price Add Cart
KI2602ARN-50910 mg$432
ARN-50925 mg$864
ARN-50950 mg$1552
ARN-509100 mg$2032
ARN-509200 mg$3250
ARN-509500 mg$6502
ARN-5091 g$10400

Chemical Characteristic

Product NameARN-509
CAS No.956104-40-8
Molecular Weight 477.43
FormulaC21H15F4N5O2S
Chemical Name4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide
SmilesC(=O)(c1c(cc(cc1)N1C2(CCC2)C(=O)N(C1=S)c1cnc(c(c1)C(F)(F)F)C#N)F)NC
Chemical Structure

Biological activities

ARN-509 is a selective and competitive AR inhibitor. ARN-509 inhibits nuclear translocation and DNA binding of the receptor, thereby modulating expression of genes that drive prostate cancer growth.[1] The IC50 of ARN-509 against AR is 16 nM that is 7- to 10-fold greater affinity than the clinically approved antiandrogen, bicalutamide (median IC50 = 160 nM). In vivo, ARN-509 exhibits antitumor activity in a castration-sensitive xenograft model of prostate cancer and antiandrogenic effects in dogs that phenocopy castration.[2]

Protocols

In vivo, ARN-509 is dissolved in DMSO.[2]

References

[1] Zivi A, Changing therapeutic paradigms in castrate-resistant prostate cancer. Clin Genitourin Cancer. 2010, 8(1): 17-22.
[2] Clegg NJ, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. 2012, 72 (6): 1494-1503.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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