Cat. No. Name Size Price Add Cart
KI2570ARRY520 trifluoroacetate10 mg$517.4

Chemical Characteristic

Product NameARRY520 trifluoroacetate
SynonymsN/A
CAS No.885060-09-3
Molecular Weight 420.48
FormulaC20H22F2N4O2S.CF3CO2H
Chemical Name(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate
SmilesS1[C@](N(N=C1c1c(ccc(c1)F)F)C(=O)N(C)OC)(c1ccccc1)CCCN C(=O)(C(F)(F)F)O
Chemical Structure

Biological activities

ARRY520 trifluoroacetate is a potent and selective inhibitor of kinesin spindle protein (KSP). The IC50 of ARRY520 trifluoroacetate against human KSP is 6 nM.[1] ARRY520 trifluoroacetate inhibits the proliferation of HCT-15, NCI/ADR-RES and K562/ADR cells with EC50s of 3.7, 14 and 4.2 nM, respectively.[2] In vivo, in several subcutaneous mouse xenograft models such as HT-29 (colon), HCT-116 (colon), A2780 (ovarian) models, ARRY520 trifluoroacetate shows greater antitumor efficacy than paclitaxel.[1]

Protocols

In vivo: ARRY520 trifluoroacetate is dissolved in 25% PEG400/10% EtOH/65% saline.[1]

References

[1] Woessner R, et al. ARRY-520, a KSP inhibitor with efficacy and pharmacodynamic activity in animal models of solid tumors. Proc Am Assoc Cancer Res. 2007, 48: 1433.
[2] Woessner R, et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 2009, 29 (11): 4373-4380.

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