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Cat. No. Name Size Price Add Cart
KI1052Artemisinin200 mg$100

Chemical Characteristic

Product NameArtemisinin
SynonymsCoartem
CAS No.63968-64-9
Molecular Weight 282.33
FormulaC15H22O5
Chemical Name3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-
SmilesO1OC2(CC[C@@H]3C41[C@@H](CC[C@H]3C)[C@H](C(=O)O[C@@H]4O2)C)C
Chemical Structure

Biological activities

Artemisinin is a potent antimalarial agent. Artemisinin is isolated from Artemisia annua, L. Artemisinin kills all stages of the malaria parasite by interacting with heme to produce carbon-centered free radicals that alkylate protein and damage the micro-organelles and membranes of the parasites.[1] In vitro IC50 values of artemisinin is 10-100 nM (3-30 µg/L) in chloroquine-resistant P. falciparum strains.[2] Artemisinin inhibits the SERCA orthologue (PfATP6) of Plasmodium falciparum with Ki value of 150 nM.[3] Artemisinin also dose dependently inhibits angiogenesis in embryoid bodies and raises the level of intracellular reactive oxygen species. Artemisinin inhibits hypoxia-inducible factor-1alpha and VEGF expressions.[4] Furthermore, artemisinin induces apoptosis, activates caspase-3, increases the Bax/Bcl-2 ratio and poly(ADP-ribose) polymerase in vitro. In mice bearing HepG2 and Hep3B xenograft tumors, artemisinin inhibits tumor growth and modulates tumor gene expression.[5]

Protocols

In vitro: Artemisinin is dissolved in methanol as a 10 mM solution and stored at -20°C.[6]

References

[1] Meshnick SR, et al. Artemisinin antimalarials: mechanisms of action and resistance. Med Trop (Mars). 1998, 58(3 Suppl): 13-7.
[2] Balint GA, et al. Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmacol Ther. 2001, 90(2-3): 261-265.
[3] Eckstein-Ludwig U, et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature. 2003, 424(6951): 957-961.
[4] Wartenberg M, et al. The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab Invest. 2003, 83(11): 1647-1655.
[5] Hou J, et al. Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res. 2008, 14(17): 5519-5530.
[6] Hong YL, et al. The interaction of artemisinin with malarial hemozoin. Mol Biochem Parasitol. 1994, 63(1): 121-128.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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