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Cat. No. Name Size Price Add Cart
KI3230Asiaticoside5 mg$180

Chemical Characteristic

Product NameAsiaticoside
CAS No.16830-15-2
Molecular Weight 959.12
FormulaC48H78O19
Chemical Name[6-[[3,4-Dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyl-oxan-2-yl)oxy-oxan-2-yl]oxymethyl]-3,4,5-trihydroxy-oxan-2-yl] (1S,2R,4aS,6aS,6bR,9S,10R,11R,12aS,14bR)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,1
Smiles[C@@H]1([C@@H](CC[C@@]2(CC[C@]3([C@@]4(CCC5[C@@]([C@H]([C@@H](C[C@]5(C4CC=C3[C@@H]12)C)O)O)(C)CO)C)C)C(=O)OC1OC(C(C(C1O)O)O)COC1OC(C(C(C1O)O)OC1OC(C(C(C1O)O)O)C)CO)C)C
Chemical Structure

Biological activities

Asiaticoside (AS) is a trisaccharide triterpene that is isolated from plant Centella asiatica.[1] Asiaticoside has been widely used as antitumor, wound healing, immunomodulatory and anti-inflammatory agents and also has an anxiolytic-like effect.[1] In the aspect of anti-tumor activity, asiaticoside induces the apoptosis of tumor cells and enhances the anti-tumor activity of vincristine.[2] In the aspect of wound healing activity, asiaticoside inhibits iNOS activity and NO production during gastric ulcer healing, meanwhile, asiaticoside alleviates Gram-negative bacteria-caused infection.[3] In the aspect of anti-inflammation activity, asiaticoside attenuates the inflammation on LPS-induced acute lung injury and acute liver injury in mice through reducing the production of cytokines such as TNF-α, IL-6.[4] [5] In vitro, asiaticoside stimulates the epidermis by activating the cells of the malpighian layer in porcine skin.[6] In vivo, asiaticoside is shown to inhibit healing of experimental corneal wounds in rabbits.[7] The IC50s of asiaticoside are 412.68 µM and 343.35 µM against CYP2C19 and CYP3A4, respectively.[8]

Protocols

In vivo: Asiaticoside is dissolved in normal saline.[9]

References

[1] Zhang LN, et al. Protective effects of asiaticoside on septic lung injury in mice. Exp Toxicol Pathol. 2011 ;63(6):519-525.
[2]Huang YH, et al. Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine. Ai Zheng. 2004 ;23(12):1599-1604.
[3]Altemeier WA, et al. Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. J Immunol. 2005 ;175(5):3369-3376.
[4]Zhang Z, et al. Effects of asiaticoside on the balance of inflammatory factors of mouse's acute lung injury induced by LPS. Zhong Yao Cai. 2008 ;31(4):547-549.
[5]Zhang L, et al. Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice. Phytomedicine. 2010 ;17(10):811-819.
[6] May A. The effect of asiaticoside on pig skin in organ culture. Eur J Pharmacol. 1968 ;4(3):331-339.
[7] Callizo J, et al. Corneal wound healing in the rabbit eye: activity of a fibronectin-splitting product. Cornea. 1996 ;15(3):263-270.
[8] Winitthana T, et al. In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450. Toxicol In Vitro. 2011 ;25(4):890-896.
[9] Shukla A, et al. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother Res. 1999 ;13(1):50-54.

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