AT-406 Inhibitor CAS No. 1071992-99-8

Cat. No.	Name	Size	Price
KI0625	AT-406	5 mg	$432
	AT-406	10 mg	$592
	AT-406	50 mg	$1712
	AT-406	200 mg	$3952

Chemical Characteristic

Product Name	AT-406
Synonyms	SM406,ARRY-334543
CAS No.	1071992-99-8
Molecular Weight	561.7
Formula	C₃₂H₄₃N₅O₄
Chemical Name	(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo[1,2-a][1,5]diazocine-8-carboxamide
Smiles	N12[C@H](CCN(C[C@H](C1=O)NC(=O)[C@@H](C)NC)C(=O)CC(C)C)CC[C@@H]2C(=O)NC(c1ccccc1)c1ccccc1
Chemical Structure

Biological activities

AT-406 is an orally active antagonist of multiple inhibitor of apoptosis proteins (IAP). The IC50 of AT-406 is 1 µg/mL against SKOV3ip cells. AT-406 has significant single agent activity in 60% of human ovarian cancer cell lines examined including SKOV3ip and OVCAR-8 in vitro.^[1] AT-406 binds to XIAP BIR3, cIAP1 BIR3 and cIAP2 BIR3 proteins with Ki of 66.4, 1.9 and 5.1 nM, respectively. The IC50 of AT-406 is 225, 12.3 and 22.1 nM, against XIAP BIR3, cIAP1 BIR3 and cIAP2 BIR3 proteins, respectively. AT-406 binds to these three IAP proteins with 50??00 times higher affinities than the Smac AVPI peptide. Addition of 500 nM of XIAP BIR3 effectively suppresses caspase-9 activity and AT-406 dose-dependently restores caspase-9 activity. AT-406 effectively induces cIAP1 degradation at concentrations as low as 10 nM, consistent with its very high binding affinity to cIAP1. AT-406 effectively induces cell death in a time- and dose-dependent manner.^[2] AT-406 inhibits ovarian cancer progression in vivo. ^[1] AT-406 is very effective in inhibition of tumor growth in the MDA-MB-231 xenograft model, and has minimal toxicity to animals.^[2]

Protocols

AT-406 is dissolved in 50% acetonitrile.^[2]

References

[1] Brunckhorst MK, et al. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer Biol Ther. 2012, 13(9): 804-811. [2] Cai Q, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011, 54(8): 2714-2726.

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