AT-7519 Inhibitor CAS No. 902135-91-5

Cat. No.	Name	Size	Price
KI2613	AT-7519	10 mg	$336
	AT-7519	25 mg	$592
	AT-7519	50 mg	$950
	AT-7519	100 mg	$1872

Chemical Characteristic

Product Name	AT-7519
Synonyms	AT 7519 Hydrochloride
CAS No.	902135-91-5
Molecular Weight	418.71
Formula	C₁₆H₁₈Cl₃N₅O₂
Chemical Name	4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide;hydrochloride
Smiles	[nH]1nc(c(c1)NC(=O)c1c(cccc1Cl)Cl)C(=O)NC1CCNCC1 Cl
Chemical Structure

Biological activities

AT-7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs). AT-7519 inhibits CDK2/cyclin A,CDK4/cyclin D1, CDK5/p35 and CDK9/cyclin T1 with IC50s of 44, 67, 18 and < 100 nM, respectively. AT-7519 is also been found to against several tumor cell lines such as HCT116 with an IC50 of 54 nM.^[1] In vitro, AT-7519 shows potent antiproliferative activity (40-940 nM) in a panel of human tumor cell lines. Meanwhile, AT-7519 causes cell cycle arrest followed by apoptosis in human tumor cells and inhibits tumor growth in human tumor xenograft models.^[2]

Protocols

In vitro, AT-7519 is dissolved in DMSO.^[2]

References

[1] Pevarello P, Bischoff J R, Mercurio C. Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors. Checkpoint Controls and Targets in Cancer Therapy. Humana Press, 2009, 235-244. [2] Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol Cancer Ther. 2009, 8 (2): 324-332.

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