Azacitidine Inhibitor CAS No. 320-67-2

Cat. No.	Name	Size	Price	Add Cart
KI0960	Azacitidine	200 mg	$496

Chemical Characteristic

Product Name	Azacitidine
Synonyms	Vidaza, 5-azacytidine, Mylosar, Ladakamycin
CAS No.	320-67-2
Molecular Weight	244.2
Formula	C₈H₁₂N₄O₅
Chemical Structure

Biological activities

Azacitidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is a potential chemotherapeutic agents for cancer. Azacitidine is used in the treatment of myelodysplastic syndrome. The IC50 values of azacitidine in six ovarian cancer cell lines (A2780, 2008/C13, Hey, NMP-1, OVCAR3, and SKOV3) range from 10.4-42.2 µM. In vitro, azacitidine pretreatment followed by 48-hour cotreatment with azacitidine and carboplatin significantly inhibits growth in 2008/C13 and Hey cells. Sequential treatment with azacitidine and carboplatin also increases cleaved caspase-3 and -8 in 2008/C13 cells.^[1] Azacitidine (1-20 µM) induces apoptosis in human myeloma cell lines and primary multiple myeloma cells. Similarly, azacitidine prolongs survival from 24.5 days to 32 days in the 5T33MM murine model of systemic myelomatosis.^[2] In mice bearing L1210/0 or L1210/ara-C tumors, azacitidine produces a less than or equal to 23% increase in life-span (ILS). Administration of azacitidine 3-hours after 3-deazauridine produces about an 80% ILS among mice bearing L1210/ara-C (resistant to cytarabine) tumors, but no more than an approximately 20% ILS among mice bearing L1210/0 (sensitive to cytarabine) tumors.^[3]

Protocols

In vitro: Azacitidine is dissolved in distilled water.^[1]

References

[1] Li Y, et al. Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis. Am J Obstet Gynecol. 2009, 200(2):177.e1-9. 閵嗏偓閵嗏偓 [2] Khong T, et al. The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma. Haematologica. 2008, 93(6): 860-869. 閵嗏偓閵嗏偓 [3] Li ZR, et al. Effect of 3-deazauridine on the metabolism, toxicity, and antitumor activity of azacitidine in mice bearing L1210 leukemia sensitive and resistant to cytarabine. Cancer Treat Rep. 1983, 67(6): 547-554. 閵嗏偓閵嗏偓

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