Cat. No. Name Size Price Add Cart
KI3679AZD10805 mg$460
AZD108025 mg$1480

Chemical Characteristic

Product NameAZD1080
CAS No.612487-72-6
Molecular Weight 334.37
FormulaC19H18N4O2
Chemical Name2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile
Smiles[nH]1c(c(c2cc(ccc12)C#N)c1ccc(cn1)CN1CCOCC1)O
Chemical Structure

Biological activities

AZD1080 is a potent and selective GSK3 inhibitor that demonstrates peripheral target engagement in Phase 1 clinical studies. AZD1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain [1]. In vitro, AZD-5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). AZD-5438 exhibits antiproliferative activity in human tumor cell lines. In vivo, it can be used by 10 ?M/kg in mice, and it blocks cell cycling at G2-M, S and G1 phases; and itreduces the proportion of actively cycling cells [2].

References

[1] Georgievska B, Sandin J, Doherty J, et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013, 125(3):446-456.
[2] Byth KF, Thomas A, Hughes G, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009, 8(7):1856-1866.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.