Cat. No. Name Size Price Add Cart
KI1494AZD24615 mg$272
AZD246125 mg$912

Chemical Characteristic

Product NameAZD2461
CAS No.1174043-16-3
Molecular Weight 395.43
FormulaC22H22FN3O3
Chemical Name4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
Smilesc1(=O)[nH]nc(c2ccccc12)Cc1cc(c(cc1)F)C(=O)N1CCC(CC1)OC
Chemical Structure

Biological activities

AZD2461 is a novel PARP (poly (ADP-ribose) polymerase) inhibitor. AZD2461 is also a poor P-glycoprotein substrate. AZD2461 completely inhibits the PARP activity for several hours. The amount of PAR returns to baseline levels 24 hours after treatment with AZD2461. Mice treated with AZD2461 clearly exhibits increased survival compared with olaparib-treated mice. Acquired AZD2461 resistance has an epithelial-to-mesenchymal transition phenotype. Long-term AZD2461 treatment is well tolerated.[1]

Protocols

In vivo: AZD2461 is diluted in 0.5% w/v hydroxypropyl methylcellulose in deionized water to a concentration of 10 mg/mL.[1]

References

[1] Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, Doroshow JH, Cranston A, Martin NM, Lau A, O'Connor MJ, Ganesan S, Borst P, Jonkers J, Rottenberg S. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013, 3(1): 68-81.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.