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Cat. No. Name Size Price Add Cart
KI0697Azithromycin25 mg$155.2
Azithromycin50 mg$272

Chemical Characteristic

Product NameAzithromycin
SynonymsZithromax, Azithrocin, Azin, CP 62993
CAS No.83905-01-5
Molecular Weight 748.98
FormulaC38H72N2O12
Chemical Structure

Biological activities

Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin prevents bacteria from growing by interfering with their protein synthesis. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. The MIC of azithromycin against the strains of H. Influenza ranges from 0.06 to 1 mg/L.[1] The MIC90 value for azithromycin in S. Typhi and S. Paratyphi is 24 mug/mL.[2] The pre- and post-treatment MICs of azithromycin against isolate of Neisseria gonorrhoeae are 0.125 mg/L and 3 mg/L.[3] Azithromycin inhibits the majority of gram-positive organisms at less than or equal to 1 µg/mL. Azithromycin displays cross-resistance to erythromycin-resistant Staphylococcus and Streptococcus isolates.[4] In mouse models, azithromycin is 10-fold more potent than erythromycin and four other antibiotics against an anaerobic infection produced by Fusobacterium necrophorum. Similarly, azithromycin is effective against established tissue infections induced by Salmonella enteritidis (liver and spleen) and Staphylococcus aureus (thigh muscle).[5] In mice infected with Brucella melitensis, azithromycin treatment (50 mg/kg/day i.p.) achieves a significantly better cure rate than controls.[6]

Protocols

In vivo: Azithromycin at a dose of 50 mg/kg/day, is dissolved in dimethyl sulfoxide.[7]

References

[1] Goldstein FW, et al. Bacteriostatic and bactericidal activity of azithromycin against Haemophilus influenzae. J Antimicrob Chemother. 1990, 25 Suppl A: 25-28.
[2] Capoor MR, et al. In vitro activity of azithromycin, newer quinolones and cephalosporins in ciprofloxacin-resistant Salmonella causing enteric fever. J Med Microbiol. 2007, 56(Pt 11): 1490-1494.
[3] Young H, et al. Azithromycin and erythromycin resistant Neisseria gonorrhoeae following treatment with azithromycin. Int J STD AIDS. 1997, 8(5): 299-302.
[4] Retsema J, et al. Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Antimicrob Agents Chemother. 1987, 31(12): 1939-1947.
[5] Girard AE, et al. Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrob Agents Chemother. 1987, 31(12): 1948-1954.
[6] Lang R, et al. Therapeutic effects of roxithromycin and azithromycin in experimental murine brucellosis. Chemotherapy. 1994, 40(4): 252-255.

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