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Cat. No. Name Size Price Add Cart
KI3250Baicalin10 mg$124

Chemical Characteristic

Product NameBaicalin
CAS No.21967-41-9
Molecular Weight 446.36
FormulaC21H18O11
Chemical Name(2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
SmilesO1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1Oc1cc2c(c(c1O)O)c(=O)cc(o2)c1ccccc1)O)O)O)C(=O)O
Chemical Structure

Biological activities

Baicalin is one of the main active compounds isolated from the dried root of Scutellaria baicalensis Georgi. Baicalin possesses anti-inflammatory, antioxidant and antitumor properties. Baicalin is widely used as a traditional herbal medicine to treat various infectious and allergic diseases. Baicalin selectively binds to several chemokines, including stromal cell-derived factor 1α, IL-8, macrophage infammatory protein (MIP)-1β, monocyte chemotactic protein (MCP)-2, and lymphotactin. Baicalin also blocks the proliferative effect of platelet-derived growth factor on vascular smooth muscle cells.[1] Baicalin significantly inhibits cell viability in lung cancer cells (A549 and LLC cells) with IC50s of 20.79 and 30.53 µM, respectively, following 72 hours drug exposure. [2] Baicalin effectively decreases the permeability of blood-brain barrier, promotes transcription and expression of TJ proteins (claudin-5 and ZO-1), and reduces the levels of PKC.[3] Baicalin markedly inhibits replication of human immunodeficiency virus type 1 (HIV-1) in a concentration-dependent manner in normal peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin (PHA) in vitro. Baicalin inhibits HIV-1 replication with an IC50 of 0.5 µg/mL.[4] Baicalin (200 mM) inhibits proliferation of SW620 cells and increases activities of caspase-3, -8, and -9 in SW620. [5] In vivo, baicalin suppresses tumor growth and prolongs survival in C57BL/6 mice bearing LLC tumor and nude mice bearing A549 carcinoma without systemic toxicity. [2] In vivo, baicalin (50 mg/kg/day, i.p.) treatment inhibits 55% of tumor growth in xenografted nude mice by 4 weeks.[5]

Protocols

In vitro, baicalin is dissolved in sterile DMSO.[5]

References

[1] Krakauer T, et al. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. FEBS Lett. 2011, 500 (1-2): 52-55.
[2] Du G, et al. Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-1alpha inhibition. Eur J Pharmacol. 2010, 630(1-3): 121-130.
[3] Zhu H, et al. Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells. J Ethnopharmacol. 2012, 141(2): 714-720.
[4] Kitamura K, et al. Baicalin, an inhibitor of HIV-1 production in vitro. Antiviral Res. 1998, 37(2): 131-140.
[5] Chen WC, et al. Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. Molecules. 2012, 17(4): 3844-3857.

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