Bay 60-7550 Inhibitor CAS No. 439083-90-6

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Chemical Characteristic

Product Name	Bay 60-7550
CAS No.	439083-90-6
Molecular Weight	476.6
Formula	C₂₇H₃₂N₄O₄
Chemical Name	2-?[(3,?4-?dimethoxyphenyl)methyl]-?7-?[(1R)-?1-?hydroxyethyl]-?4-?phenylbutyl]-?5-?methyl-?imidazo[5,?1-?f][1,?2,?4]triazin-?4(1H)-?one
Smiles	n12[nH]c(nc(=O)c1c(nc2[C@@H](CCCc1ccccc1)[C@@H](C)O)C)Cc1cc(c(cc1)OC)OC
Chemical Structure

Biological activities

Bay 60-7550 is a potent and selective PDE2 inhibitor. Bay 60-7550 inhibits the activity of PDE2 purified from bovine heart and human recombinant PDE2 with IC50s of 2.0 and 4.7 nM, respectively.^[1] BAY 60-7550 improves memory functions by enhancing neural plasticity. In cell culture and slice models, BAY 60-7550 increases neuronal cGMP levels in response to a stimulus of the NO/cGMP pathway.^[2] BAY 60-7550 (10 µM) significantly reduces the effect of SNAP on the ISO-induced cAMP response in the PKA-RII compartment.^[3] Furthermore, Bay 60-7550 enhances long-term potentiation of synaptic transmission without altering basal synaptic transmission.^[1] In vivo, oral administration of BAY 60-7550 improves memory consolidation in rodent models of learning and memory.^[2] Bay 60-7550 (3mg/kg i.p.) significantly attenuates the BSO-induced decrease in total antioxidant capacity and increase in the expression of NADPH oxidase subunits, both in hypothalamus and amygdala.^[4]

Protocols

In vitro, Bay 60-7550 is dissolved in DMSO.^[1]

References

[1] Boess FG, et al. Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology. 2004, 47(7):1081-1092. [2]Hendrix, Martin. "Selective inhibitors of cGMP phosphodiesterases as procognitive agents." BMC Pharmacology. 2005, S5. [3] Stangherlin A, et al. cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circ Res. 2011, 108(8):929-939. [4] Masood A, et al. Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice. J Pharmacol Exp Ther. 2008, 326(2):369-379.

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