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Cat. No. Name Size Price Add Cart
KI3295BeloranibQuoteQuote

Chemical Characteristic

Product NameBeloranib
CAS No.251111-30-5
Molecular Weight 499.64
FormulaC29H41NO6
Chemical Name(E)-(3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl 3-(4-(2-(dimethylamino)ethoxy)phenyl)acrylate
SmilesC(=O)(/C=C/c1ccc(cc1)OCCN(C)C)OC1CCC2(CO2)[C@H]([C@@H]1OC)[C@]1(O[C@@H]1CC=C(C)C)C
Chemical Structure

Biological activities

Beloranib is a methionine aminopeptidase 2 (METAP2) inhibitor.[1] Beloranib is under development in the treatment of obesity. Administration of beloranib causes profound weight loss in mice, which thereafter achieves ideal body weight. In dogs receiving beloranib, weight loss is associated with improved glycemic control and an apparent reduction in demand for insulin secretion. [2]

References

[1] Shea J, et al. The obesity epidemic. Clin Chem. 2012, 58(6): 968-973.
[2] Powell AG, et al. New drug targets for the treatment of obesity. Clin Pharmacol Ther. 2011, 90(1): 40-51.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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