Biperiden hydrochloride Inhibitor CAS No. 1235-82-1 - Biperiden hydrochloride Supplier

Home »
Biochemical Products »
Small Molecule Inhibitors and Antagonist »
Biperiden-hydrochloride

Small Molecule Inhibitors and Antagonist

Anti-virus

Mitogen-activated Protein Kinases (MAPK)

PI3K/Akt/mTOR

Proteases/Proteasome

Protein Tyrosine Kinases (PTK)

Cat. No.	Name	Size	Price	Add Cart
KI0918	Biperiden hydrochloride	10 mg	$154
KI0918	Biperiden hydrochloride	50 mg	$432

Chemical Characteristic

Product Name	Biperiden hydrochloride
Synonyms	Akineton
CAS No.	1235-82-1
Molecular Weight	347.92
Formula	C₂₁H₃₀ClNO
Chemical Structure

Biological activities

Biperiden hydrochloride is an antiparkinsonian agent of the anticholinergic type. Biperiden hydrochloride is used for the adjunctive treatment of all forms of Parkinson's disease. Biperiden hydrochloride inhibits N-Methyl-D-aspartate-(NMDA-) evoked [³H]acetylcholine release with a functional Ki value of 8.8 µM in rabbit caudate nucleus slices.^[1] Biperiden hydrochloride antagonizes muscarinic receptor (mAChR M) subtypes mAChR M1, mAChR M4, mAChR M3, mAChR M2 and mAChR M5 receptors with Ki values of 0.48, 2.4, 3.9, 6.3 and 6.3 nM, respectively.^[2] Biperiden hydrochloride treatment (4 mg) results in 10-45% mAchR occupancy in the frontal cortex.^[3]

Protocols

In vivo: Biperiden hydrochloride is dissolved in distilled water.^[4]

References

[1] Jackisch R, et al. The antiparkinsonian drugs budipine and biperiden are use-dependent (uncompetitive) NMDA receptor antagonists. Eur J Pharmacol. 1994, 264(2): 207-211. 閵嗏偓閵嗏偓 [2] Bolden C, et al. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther. 1992, 260(2): 576-580. 閵嗏偓閵嗏偓 [3] Sudo Y, et al. Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 1999, 64(8): PL99-104. 閵嗏偓閵嗏偓 [4] Matsuo H, et al. Propiverine-induced Parkinsonism: a case report and a pharmacokinetic/pharmacodynamic study in mice. Pharm Res. 2000, 17(5): 565-571.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.