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Cat. No. Name Size Price Add Cart
KI1073BMS 30314110 mg$230

Chemical Characteristic

Product NameBMS 303141
CAS No.943962-47-8
Molecular Weight 424.3
FormulaC19H15Cl2NO4S
Chemical Name3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)benzenesulfonamide
Smilesc1(c(c(cc(c1)Cl)Cl)O)S(=O)(=O)Nc1cc(ccc1OC)c1ccccc1
Chemical Structure

Biological activities

BMS 303141 is an ATP citrate lyase (ACL) inhibitor with an IC50 of 130 nM for human recombinant ACL. In HepG2 cells, BMS 303141 inhibits total lipid syntheses with an IC50 of 8 µM. Under identical incubation conditions, BMS 303141 has no cytotoxicity up to 50 µM. In mice, BMS 303141 shows an oral bioavailability of 55% and a relatively short half-life of 2.1 hours. Chronic oral dosing of BMS 303141 (20 days, daily dose of 10 or 100 mg/kg) in high-fat fed mice lowers plasma cholesterol and triglyceride. Besides, fasting plasma glucose is lowered by 48% and 32% for 10 and 100 mg/kg doses of BMS 303141, respectively. In high-fat??ed mice, BMS 303141 also reduces weight gain.[1] BMS 303141 lowers plasma cholesterol, triglycerides, and glucose in high-fat??ed mice.[2]

Protocols

In vitro: BMS 303141 is dissolved in DMSO. [2]

References

[1] Li JJ, et al. 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007, 17(11): 3208-3211.
[2] Ma ZP, et al. A novel direct homogeneous assay for ATP citrate lyase. J Lipid Res. 2009, 50(10): 2131-2135.

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Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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