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KI3325BMS-74080810 mg$820

Chemical Characteristic

Product NameBMS-740808
CAS No.280118-23-2
Molecular Weight 588.58
FormulaC31H27F3N6O3
Chemical Structure

Biological activities

BMS-740808 is an orally bioavailable, highly potent, and selective inhibitor of Factor Xa with a Ki value of 30 pM. BMS-740808 has a rapid onset of inhibition (2.7x107 M-1 s-1) in vitro. BMS-740808 is highly selective (>1000-fold over other proteases) and efficacious in the AVShunt thrombosis model.[1]

References

[1] Pinto DJ, et al. 1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)- hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. Bioorg Med Chem Lett. 2006, 16(15): 4141-4147.
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