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Cat. No. Name Size Price Add Cart
KI0402BMS-7900525 mg$272
BMS-79005210 mg$512
BMS-79005250 mg$1552
BMS-790052200 mg$3952

Chemical Characteristic

Product NameBMS-790052
CAS No.1009119-64-5
Molecular Weight 738.89
FormulaC40H50N8O6
Chemical NameN,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid C,C'-dimethyl ester
SmilesC(=O)(NC(C(=O)N1[C@@H](CCC1)c1ncc([nH]1)c1ccc(cc1)c1ccc(cc1)c1cnc([nH]1)C1N(CCC1)C(=O)[C@H](C(C)C)NC(=O)OC)C(C)C)OC
Chemical Structure

Biological activities

BMS-790052 is the most potent hepatitis C virus (HCV) replication inhibitor. BMS-790052 targets nonstructural protein 5A (NS5A). BMS-790052 is highly efficacious against genotype 1 replicons. BMS-790052 also displays robust genotype 1 anti-HCV activity. [1] The mean EC50 of BMS-790052 against genotype 1a and 1b replicons is 50 and 9 pM, respectively. Combination of BMS-790052 with with interferon-α/ribavirin, an inhibitor of NS3 protease (ITMN-191), produces additive-to-synergistic effects. BMS-790052 potently inhibits the JFH-1 genotype 2a infectious virus that replicates in cell culture with an EC50 of 28 pM. Additionally, BMS-790052 has similar potency among Huh-7, HeLa and HEK293T cells.[2] BMS-790052 inhibits genotype 2a JFH1 replicon cells and cell culture infectious virus with EC50 of 46.8 and 16.1 pM, respectively. BMS-790052 inhibits JFH1-L31M (Renilla luciferase) and JFH1-WT (β-lactamase) replicons with EC50 of 6.4 and 0.07 nM, respectively.[1] For genotype 1b, BMS-790052 retains subnanomolar potency against all variants with single amino acid substitutions, indicating that multiple mutations will likely be required for significant in vivo resistance in this genetic background. Importantly, BMS-790052-resistant variants remain completely sensitive to alpha interferon and small-molecule inhibitors of HCV protease and polymerase.[3]

References

[1] Fridell RA, et al. Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052. J Virol. 2011, 85(14): 7312-7320.
[2] Gao M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010, 465(7294): 96-100.
[3] Fridell RA, et al. Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob Agents Chemother. 2010, 54(9): 3641-50.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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