Cat. No. Name Size Price Add Cart
KI2854BMS-9115435 mg$650
BMS-91154310 mg$910
BMS-91154320 mg$1560
BMS-91154350 mg$2600
BMS-911543100 mg$4160
BMS-911543200 mg$6500
BMS-9115431 g$11960

Chemical Characteristic

Product NameBMS-911543
CAS No.1271022-90-2
Molecular Weight 432.53
FormulaC23H28N8O
Chemical NameN,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide??
Smilesc12c(c3c(c(n1)Nc1nn(c(c1)C)C)ncn3C)cc(n2CC)C(=O)N(C1CC1)C1CC1
Chemical Structure

Biological activities

BMS-911543 is a potent JAK2 inhibitor with an IC50 of 1.1 nM. BMS-911543 also inhibits JAK1, JAK3, and TYK2 with IC50s of 356, 73, and 66 nM, respectively. In vitro, BMS-911543 shows anti-proliferative responses in primary progenitor cells isolated from patients with JAK2(V617F)-positive myeloproliferative neoplasms (MPNs). In mice model in vivo, BMS-911543 treatment also has potent and sustained JAK2 pathway suppression.[1]

Protocols

BMS-911543 is prepared in DMSO as a 10mM stock solution or in 20% citrate/80% PEG400 vehicle for in vitro or in vivo experiments, respectively.[1]

References

[1] Purandare AV, et al. Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. Leukemia. 2012, 26(2): 280-288.

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