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Cat. No. Name Size Price Add Cart
KI3235BreviscapineQuoteQuote

Chemical Characteristic

Product NameBreviscapine
CAS No.116122-36-2
Molecular Weight 462.08
FormulaC21H18O12
Chemical Name(2S,3S,4S,5R,6S)-6-[5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
SmilesO(C1[C@H](O)[C@@H](O)[C@H](O)[C@H](O1)C(=O)O)c1cc2c(c(=O)cc(o2)c2ccc(cc2)O)c(c1O)O
Chemical Structure

Biological activities

Breviscapine is a plant flavonoid that is isolated from Erigerin breviscapus.[1] Breviscapine is widely used for the treatment of cerebrovascular diseases and cerebrovascular injury.[1] Breviscapine can relieve the paralysis caused by cerebral infarction, hypertension and chronic arachnoiditis along with their sequelae.[2] Furthermore, breviscapine has anticoagulation effect and can protect against cerebral ischemia-reperfusion injury.[2] In vitro, breviscapine inhibits the growth of human hepatocellular carcinoma cell line HepG2 and exert proapoptotic effect on HepG2 cells.[2] Meanwhile, breviscapine protects the injury of cortical neuron and decreases the intracellular calcium overloading induced by H2O2.[3] In vivo, in the model of vascular dementia rats, breviscapine (2 mg/kg for 14 days) improves the performance of learning and memory, decreases the level of lipid peroxidation and free radicals, and attenuates the pathological alterations.[3]

Protocols

In vitro: Breviscapine is dissolved in 0.1% DMSO.[2]

References

[1] Zhong H, et al. Multivesicular liposome formulation for the sustained delivery of breviscapine. Int J Pharm. 2005, 301(1-2): 15-24.
[2] Wu Y, et al. Breviscapine-induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Phytother Res. 2010, 24(8):1188-1194.
[3] Xiong Z, et al. Protective effects of breviscapine on ischemic vascular dementia in rats. Biol Pharm Bull. 2006, 29(9): 1880-1885.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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