Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI0689Budesonide50 mg$154

Chemical Characteristic

Product NameBudesonide
SynonymsRhinocort, Pulmicort, Entocort, Symbicort, Noex,
CAS No.51333-22-3
Molecular Weight 430.53
FormulaC25H34O6
Chemical Structure

Biological activities

Budesonide is a glucocorticoid steroid. Budesonide is used for the treatment of asthma and non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. Budesonide potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with an EC50 of 0.05 nM. Budesonide induces transcription of the β1-receptor with an EC50 of 1.1 nM. Budesonide causes a marked increase in DNA binding with an EC50 of 6.4 nM. IL-1β-stimulated 3鑴?#954;B-activated luciferase activity is inhibited by budesonide in a concentration-dependent manner with an IC50 of 0.027 nM.[1] The IC50 of budesonide are 22, 1.4 and 0.09 nM for inhibition of GM-CSF production, ICAM-1 and VCAM-1 upregulation by human lung fibroblasts after IL-1β stimulation, respectively. IL-8 production after IL-1β stimulation is significantly inhibited by budesonide with an IC50 of 0.15 nM. [2] Budesonide inhibits vascular endothelial growth factor (VEGF) secretion as well as mRNA expression in ARPE-19 cells in a dose-dependent manner. [3] Budesonide is proven to be a highly effective agent in preventing the development of lung tumors in A/J mice. [4]

Protocols

Budesonide is dissolved in 96% ethanol in a concentration of 10-2M. [2]

References

[1] Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999, 127(4): 1003-1011. 閵嗏偓閵嗏偓
[2] Spoelstra FM, et al. Additive anti-inflammatory effect of formoterol and budesonide on human lung fibroblasts. Thorax. 2002, 57(3): 237-241. 閵嗏偓閵嗏偓
[3] Kompella UB, et al. Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression. Invest Ophthalmol Vis Sci. 2003, 44(3): 1192-1201. 閵嗏偓閵嗏偓
[4] Yao R, et al. Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions. Oncogene. 2004, 23(46): 7746-7752. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook