Bumetanide Inhibitor CAS No. 28395-03-1

Cat. No.	Name	Size	Price	Add Cart
KI0920	Bumetanide	50 mg	$154

Chemical Characteristic

Product Name	Bumetanide
Synonyms	Bumex
CAS No.	28395-03-1
Molecular Weight	364.42
Formula	C₁₇H₂₀N₂O₅S
Chemical Structure
Documents	MS

Biological activities

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide (10-50 µM) blocks Na⁺-K⁺-Cl^- cotransport in Ehrlich ascites cells.^[1] Bumetanide, applied to the lumen, reversibly suppresses the lumen positive potential (PDt) of the rabbit TALH. Bumetanide also suppresses the PDt in the absence of Na⁺ where the NaCl of the artificial solutions is replaced by choline chloride.^[2] Bumetanide inhibits vascular endothelial cell proliferation measured by direct counting of cells and by DNA synthesis in vitro.^[3] Furthermore, blocking the Na⁺-K⁺-Cl^- transporter with bumetanide prevents outward Cl^- flux and causes a more negative GABA equilibrium potential (EGABA) in immature neurons. Bumetanide exhibits acute anticonvulsant effects in the neonatal brain under conditions of in vivo models of epilepsy.^[4] Bumetanide (0.5 mg/kg) increases the baseline hippocampal afterdischarge threshold and shortens the after discharge duration in Wistar rats.^[5]

Protocols

In vitro: Bumetanide is dissolved in DMSO.^[3]

References

[1] Hoffmann EK, et al. The number of chloride-cation cotransport sites on Ehrlich ascites cells measured with [³H]bumetanide. Am J Physiol. 1986, 250(5 Pt 1): C688-C693. 閵嗏偓閵嗏偓 [2] Imai M, et al. Effect of bumetanide and furosemide on the thick ascending limb of Henle's loop of rabbits and rats perfused in vitro. Eur J Pharmacol. 1977, 41(4): 409-416. 閵嗏偓閵嗏偓 [3] Panet R, et al. Bumetanide and furosemide inhibited vascular endothelial cell proliferation. J Cell Physiol. 1994, 158(1): 121-127. 閵嗏偓閵嗏偓 [4] Dzhala VI, et al. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol. 2008, 63(2): 222-235. 閵嗏偓閵嗏偓 [5] Mazarati A, et al. Bumetanide inhibits rapid kindling in neonatal rats. Epilepsia. 2009, 50(9): 2117-2122. 閵嗏偓閵嗏偓

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services