Busulfan Inhibitor CAS No. 55-98-1

Cat. No.	Name	Size	Price	Add Cart
KI1076	Busulfan	200 mg	$100

Chemical Characteristic

Product Name	Busulfan
Synonyms	Myleran, Busulfex
CAS No.	55-98-1
Molecular Weight	246.3
Formula	C₆H₁₄O₆S₂
Chemical Name	4-methylsulfonyloxybutyl methanesulfonate
Smiles	C(CCCOS(=O)(=O)C)OS(=O)(=O)C
Chemical Structure

Biological activities

Busulfan is an alkylating agent having a selective immunosuppressive effect on bone marrow. Busulfan has been used in the palliative treatment of chronic myeloid leukemia. Additional effects resulting from the cytotoxicity of busulfan in hematological and other tissues include lethality, sterility, teratogenicity, and alteration of immune function. Busulfan is mutagenic to microorganisms, mammalian cells in culture, Drosophila, and rodents. Busulfan is also considered potentially carcinogenic to humans.^[1] In vitro, busulfan induces activin A (a member of the transforming growth factor superfamily) in a time- and concentration-dependent manner in the human cell line ECV304. Busulfan also significantly induces both tissue factor and cyclooxygenase 2. In a parallel in vivo study, busulfan treatment significantly increases serum activin A concentration.^[2] In adult female mice, busulfan treatment (15, 30, or 60 mg/kg) dose-dependently increases the frequency of chromosome aberrations in bone marrow. ^[3]

References

[1] Bishop JB, et al. Toxicological review of busulfan (Myleran). Mutat Res. 1986, 168(1): 15-45. [2] Dressel D, et al. Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease. Clin Pharmacol Ther. 2003, 74(3): 264-274. [3] Basler A, et al. Cytogenetic effects of busulfan in vivo on bone marrow cells and oocytes of adult mice and liver cells of transplacentally exposed embryos. Environ Mutagen. 1979, 1(3): 233-238.

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