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Cat. No. Name Size Price Add Cart
KI0961Calcitriol2 mg$192
Calcitriol5 mg$432
Calcitriol25 mg$1712

Chemical Characteristic

Product NameCalcitriol
SynonymsCalcijex, Silkis, Rocaltrol, Topitriol, Cholecalciferol
CAS No.32222-06-3
Molecular Weight 416.64
FormulaC27H44O3
Chemical Structure

Biological activities

Calcitriol is the hormonally active form of vitamin D with three hydroxyl groups (abbreviated 1,25-(OH)2D3). Calcitriol increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, and possibly increasing the release of calcium into the blood from bone. Calcitriol has antiproliferative and differentiating effects on a variety of human tissues and tumors, such as human prostate cancer cells in culture (LnCaP, DU145, PC3).[1] Calcitriol stimulates growth and prostate-specific antigen production by LNCaP cells in a dose-dependent fashion in the absence of androgens.[2] In addition, calcitriol (0.1 to 100 nM) produces a dose-dependent inhibitory effect on the progression of cells into the cell cycle and into apoptosis in normal dog parathyroid glands.[3] In an in vivo model of androgen-insensitive metastatic prostate cancer, the rat Dunning MAT LyLu prostate cancer model, calcitriol significantly inhibits prostate cancer metastasis.[4] Treatment of murine squamous cell carcinoma (SCCVII/SF) or human prostatic adenocarcinoma (PC-3) tumor-bearing mice with calcitriol prior to paclitaxel results in substantially greater growth inhibition than is achieved with either agent alone.[5]

Protocols

In vitro: Calcitriol is dissolved in lipiodol.[6]

References

[1] Reichel H, et al. The role of the vitamin D endocrine system in health and disease. N Engl J Med. 1989, 320(15): 980-991. 閵嗏偓閵嗏偓
[2] Miller GJ, et al. The human prostatic carcinoma cell line LNCaP expresses biologically active, specific receptors for 1 alpha,25-dihydroxyvitamin D3. Cancer Res. 1992, 52(3): 515-520.
[3] Canalejo A, et al. The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J Am Soc Nephrol. 2000, 11(10): 1865-1872. 閵嗏偓閵嗏偓
[4] Lokeshwar BL, et al. Inhibition of prostate cancer metastasis in vivo: a comparison of 1,23-dihydroxyvitamin D (calcitriol) and EB1089. Cancer Epidemiol Biomarkers Prev. 1999, 8(3): 241-248. 閵嗏偓閵嗏偓
[5] Hershberger PA, et al. Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis. Clin Cancer Res. 2001, 7(4): 1043-1051. 閵嗏偓閵嗏偓
[6] Wu FS, et al. Calcitriol inhibits the growth of MHCC97 heptocellular cell lines by down-modulating c-met and ERK expressions. Liver Int. 2007, 27(5): 700-707. 閵嗏偓閵嗏偓

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