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Cat. No. Name Size Price Add Cart
KI0680Captopril50 mg$154

Chemical Characteristic

Product NameCaptopril
SynonymsCapoten, SQ 14,225
CAS No.62571-86-2
Molecular Weight 217.29
FormulaC9H15NO3S
Chemical Structure

Biological activities

Captopril is an angiotensin-converting enzyme (ACE) inhibitor. The IC50 of captopril is 22 nM against angiotensin-converting enzyme. Minimum effective dose of captopril is 1.25 mg/kg. [1] Captopril in vitro (50閳?00 µg/mL) increases 3H-TdR incorporation in unstimulated and mitogen-stimulated cultures of rat lymphocytes. Unseparated spleen and lymph node cells of rats orally treated with captopril (50 mg/kg/day鑴?) reveals decreased basal and mitogen stimulated 3H-TdR incorporation.[2] Captopril acts directly and specifically on capillary endothelial cells, inhibiting their chemotaxis with a biphasic dose-response curve. [3] Captopril scavenges superoxide anions in vitro independent of an action on ACE.[4] Captopril enhances lymphocyte thymidine uptake induced by 25 µg/mL phytohaemagglutinin-P. Captopril results in decreased granuloma size by inhibition of angiotensin-converting enzyme in animals.[5] Captopril also inhibits angiogenesis and slows the growth of experimental tumors in rats.[3] Captopril intravenously (5 mg/kg) results in a 40% to 60% return to active shortening within 60 minutes of reperfusion. Captopril improves postischemic contractile derangements by a mechanism independent of ACE inhibition. [4]

Protocols

In vitro: Captopril is dissolved in saline.[1]

References

[1] Fujita H, et al. LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 1999, 44(1-2): 123-127. 閵嗏偓閵嗏偓
[2] Binderup L, et al. Captopril (SQ 14,225): in vitro and in vivo influence on the proliferative response of rat lymphocytes. Experientia. 1982, 38(3): 399-401. 閵嗏偓閵嗏偓
[3] Volpert OV, et al. Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats. J Clin Invest. 1996, 98(3): 671-679. 閵嗏偓閵嗏偓
[4] Westlin W, et al. Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals? Circulation. 1988, 77(6 Pt 2): I30-I39. 閵嗏偓閵嗏偓
[5] Simon MR, et al. Captopril enhances in vitro human lymphocyte thymidine incorporation. Agents Actions. 1984, 15(5-6): 525-528. 閵嗏偓閵嗏偓

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