Cat. No. Name Size Price Add Cart
KI0923Carboplatin50 mg$110
Carboplatin100 mg$140
Carboplatin200 mg$240

Chemical Characteristic

Product NameCarboplatin
SynonymsParaplatin, Paraplatin-AQ
CAS No.41575-94-4
Molecular Weight 371.25
FormulaC6H12N2O4Pt
Chemical Structure

Biological activities

Carboplatin is an active agent for acute myeloid leukemia. The IC50 of carboplatin is 6.2 µg/mL against leukemic cell lines.[1] Carboplatin interacts with DNA to interfere with DNA repair. Cisplatin is used against some forms of cancer including mainly ovarian carcinoma, lung, head and neck cancers.[2] The combination of proanthocyanidins with carboplatin reduces the proliferation of SKOV-3 cells at lower concentrations than with either individually.[3]

References

[1] Su WC, et al. Comparison of in vitro growth-inhibitory activity of carboplatin and cisplatin on leukemic cells and hematopoietic progenitors: the myelosuppressive activity of carboplatin may be greater than its antileukemic effect. Jpn J Clin Oncol. 2000, 30(12): 562-567. 閵嗏偓閵嗏偓
[2] Wheate NJ, et al. The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton Trans. 2010, 39(35): 8113-8127. 閵嗏偓閵嗏偓
[3] Singh AP, et al. Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin. Phytother Res. 2009, 23(8): 1066-1074. 閵嗏偓閵嗏偓

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