Cefepime Inhibitor CAS No. 88040-23-7

Cat. No.	Name	Size	Price	Add Cart
KI0673	Cefepime	10 mg	$396.9

Chemical Characteristic

Product Name	Cefepime
Synonyms	Maxipime
CAS No.	88040-23-7
Molecular Weight	480.56
Formula	C₁₉H₂₄N₆O₅S₂
Smiles	[N]1(CCCC1)(C)CC1=C(N2C(SC1)[C@H](C2=O)NC(=O)/C(=N/OC)/c1nc(sc1)N)C(=O)O
Chemical Structure
Documents	HPLC MS COA

Biological activities

Cefepime is a fourth-generation cephalosporin antibiotic. Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria. Cefepime is active at low concentrations against non-cephalosporinase-producing Enterobacteriaceae (Escherichia coli, Proteus mirabilis, Salmonella spp. and Shigella spp.) with MIC50 and MIC90 values of ??0.06 mg/L and ??.12 mg/L, respectively. Cefepime inhibits ticarcillin-sensitive strains of Pseudomonas aeruginosa at concentrations of 0.5-16 mg/L. The MICs of cefepime against strains of Pseudomonas aeruginosa resistant to ticarcillin are 8-64 mg/L.^[1] The MIC90 of cefepime for extended-spectrum beta-lactamases (ESBLs)-producing strains of Enterobacter cloacae is 64 µg/mL, while for non-ESBL producers the MIC90 of cefepime is 0.5 µg/mL.^[2] In experimental infections such as meningitis, induced with various bacterial species in neonatal rats and chronic staphylococcal osteomyelitis in rabbits, cefepime administration has good antibacterial efficacy.^[3]

References

[1] Duval J, et al. In-vitro antibacterial activity of cefepime: a multicentre study. J Antimicrob Chemother. 1993, 32 Suppl B: 55-61. [2] Szab? D, et al. SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in Enterobacter cloacae. J Clin Microbiol. 2005, 43(10): 5058-5064. [3] Grassi GG, et al. Cefepime: overview of activity in vitro and in vivo. J Antimicrob Chemother. 1993, 32 Suppl B: 87-94.

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