Cephalexin Inhibitor CAS No. 15686-71-2

Cat. No.	Name	Size	Price	Add Cart
KI0857	Cephalexin	5 g	$204

Chemical Characteristic

Product Name	Cephalexin
Synonyms	Cefalexin, Keflex
CAS No.	15686-71-2
Molecular Weight	347.39
Formula	C₁₆H₁₇N₃O₄S
Chemical Structure

Biological activities

Cephalexin is cephalosporin antibiotic. The average MIC_{90 of cephalexin is 8 µg/mL against S. aureus. In contrast, the MIC50 of cephalexin is 4 µg/mL against S. aureus. ^[1] Cephalexin is a substrate of oligopeptide transporters.^[2] The IC50 of cephalexin is 1.5 ng/mL for the specificity of anti-sera in an indirect competitive enzyme-linked immunosorbent assay.^[3] Cephalexin is rapidly absorbed and excreted into the urine after single oral doses of 500 mg.^[4] Levels of cephalexin in urine are adequate to inhibit over 90% of E. coli , and P. mirabilis 閿涘畮nd 80 to 96% of Klebsiella-Aerobacter strains.^[5] The urinary excretion of cephalexin for 60 minutes is significantly reduced, and the renal concentration is markedly increased in Mate1(-/-) mice compared with Mate1(+/+) mice.^[6]}

Protocols

In vitro: Cephalexin is dissolved in phosphate buffer solution, pH 7.4.^[2]

References

[1] Sader HS, et al. Potency and spectrum reevaluation of cefdinir tested against pathogens causing skin and soft tissue infections: a sample of North American isolates. Diagn Microbiol Infect Dis. 2004, 49(4): 283-287. 閵嗏偓閵嗏偓 [2] Koga K, et al. In vitro and in situ evidence for the contribution of Labrasol and Gelucire 44/14 on transport of cephalexin and cefoperazone by rat intestine. Eur J Pharm Biopharm. 2002, 54(3): 311-318. [3] Xie H, et al. Development and validation of an immunochromatographic assay for rapid multi-residues detection of cephems in milk. Anal Chim Acta. 2009, 634(1): 129-33. [4] Braun P, et al. Cephalexin and cephaloglycin activity in vitro and absorption and urinary excretion of single oral doses in normal young adults. Appl Microbiol. 1968, 16(11): 1684-1694. [5] Thornhill TS, et al. In vitro antimicrobial activity and human pharmacology of cephalexin, a new orally absorbed cephalosporin C antibiotic. Appl Microbiol. 1969, 17(3): 457-461. 閵嗏偓閵嗏偓 [6] Watanabe S, et al.Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010, 334(2): 651-656. 閵嗏偓閵嗏偓

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