Cephradine Inhibitor CAS No. 38821-53-3

Cat. No.	Name	Size	Price	Add Cart
KI1150	Cephradine	500 mg	$184

Chemical Characteristic

Product Name	Cephradine
Synonyms	Cefradine,Velosef
CAS No.	38821-53-3
Molecular Weight	349.41
Formula	C₁₆H₁₉N₃O₄S
Chemical Name	(6R-(6alpha,7))-((Amino-1,4-cyclohexadien-1-ylacetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Smiles	N12C(=C(CS[C@@H]1C(C2=O)NC(=O)C(C1=CCC=CC1)N)C)C(=O)O
Chemical Structure

Biological activities

Cephradine is a first generation cephalosporin antibiotic. Cephradine is used in the treatment of certain infections caused by susceptible bacterial strains causing respiratory, genitourinary, gastrointestinal, skin and soft tissue, and bone and joint infections, or septicemia. Cephradine is effective against many gram-positive bacilli and cocci (other than enterococcus) and some gram-negative bacilli.Cephradine inhibits Gly-Sar uptake in CHO/hPEPT1 cells with an IC50 of 15.3 mM.^[1] Besides, cephradine has superior in-vitro activity against non-sporing anaerobic bacteria, and can be used as prophylactic agents for abdominal or vaginal hysterectomy.^[2] In addition, cephradine as a low protein bound cephalosporine antibiotic exhibits good diffusion into the tissue cage fluid.^[3] Cephradine is also used to treat urinary, bronchopulmonary and wound infections in disseminated cancer. Cephradine inhibits most strains of Pneumococcus Staphylococcus and Streptococcus pyogenes.^[4]

Protocols

Cephradine solution (0.01 mM to 50 mM) containing 3H-Gly-Sar (20 mM, 0.4 Ci/mL) is added to each well and incubated for 30 minutes at 25 °C.^[1]

References

[1] Han HK, et al. CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999, 88 (3): 347-350. [2] Davey PG, et al. Cost-benefit analysis of cephradine and mezlocillin prophylaxis for abdominal and vaginal hysterectomy. Br J Obstet Gynaecol. 1988, 95 (11): 1170- 1177. [3] Adam D, et al. Diffusion of cefradine and cefaiothin into interstitial fluid of human volunteers with tissue cages. Infection. 1978, 6 (1): 78-81. [4] Klastersky J, et al. Cephradine. Chemotherapy. 1973, 18: 191-204.

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