CI994 Inhibitor CAS No. 112522-64-2

Cat. No.	Name	Size	Price	Add Cart
KI3681	CI994	10 mg	$120
KI3681	CI994	50 mg	$460

Chemical Characteristic

Product Name	CI994
Synonyms	Tacedinaline
CAS No.	112522-64-2
Molecular Weight	269.3
Formula	C₁₅H₁₅N₃O₂
Chemical Name	4-Acetylamino-N-(2'-aminophenyl)benzamide
Smiles	C(=O)(c1ccc(cc1)NC(=O)C)Nc1c(cccc1)N
Chemical Structure

Biological activities

CI-994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 ?M and causes G1 cell cycle arrest, and CI-994 is in Phase III clinical trial in patients with Lung Cancer ^[1]. In vitro, CI-994 in combination with cytarabine (ara-C), daunorubicin and mitoxantrone, resulted in moderate synergism ^[2]. In vivo, higher dosages of CI-994 induced complete remissions. CI-994/ara-C was very active against BNML (Brown Norway rat acute myelocytic leukemia). The combinations of CI-994/daunorubicin and CI-994/mitoxantrone were also active against BNML ^[3].

References

[1] Richards D A, Boehm K A, Waterhouse D M, et al. Gemcitabine plus CI-994 offers no advantage over gemcitabine alone in the treatment of patients with advanced pancreatic cancer: results of a phase II randomized, double-blind, placebo-controlled, multicenter study. Annals of oncology.2006, 17(7): 1096-1102. [2] Loprevite M, Tiseo M, Grossi F, et al. In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2005, 15(1): 39-48. [3] Thomas M, Clarhaut J, Tranoy-Opalinski I, et al. Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy. Bioorganic & medicinal chemistry, 2008, 16(17): 8109-8116.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com