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Cat. No. Name Size Price Add Cart
KI2515CID1602004610 mg$465.4
CID1602004650 mg$1911

Chemical Characteristic

Product NameCID16020046
SynonymsN/A
CAS No.834903-43-4
Molecular Weight 425.44
FormulaC25H19N3O4
Chemical Name?4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid
SmilesC(=O)(c1ccc(cc1)N1C(=O)c2[nH]nc(c2C1c1cc(ccc1)O)c1ccc(cc1)C)O
Chemical Structure

Biological activities

CID16020046 is a selective G protein-coupled receptor 55(GPR55) antagonist. CID16020046 antagonizes agonist-induced receptor activation in yeast cells expressing human GPR55. CID16020046 (40 nM to 10 mM) inhibits GPR55 constitutive activity with an IC50 of 0.15 mM. CID16020046 inhibits LPI-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor κ of activated B cells (NF-κB) and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization. CID16020046 also reduces LPI-induced wound healing in primary human lung microvascular endothelial cells and reverses LPI-inhibited platelet aggregation.[1]

Protocols

In vitro, CID16020046 is dissolved in DMSO.[1]

References

[1] Kargl J, et al. A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013, 346(1): 54-66.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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