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Cat. No. Name Size Price Add Cart
KI3728CID201175610 mg$270

Chemical Characteristic

Product NameCID2011756
CAS No.638156-11-3
Molecular Weight 396.87
FormulaC22H21ClN2O3
Chemical Name5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furancarboxamide
Smileso1c(ccc1c1cc(ccc1)Cl)C(=O)Nc1ccc(cc1)CN1CCOCC1
Chemical Structure

Biological activities

CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells [1]. It has pan-PKD inhibitory effects (PKD2 IC50 = 0.6?0.1 ?M; PKD3 IC50 = 0.7?0.2 ?M) with similar, albeit not identical, potencies which may be expected for an ATP competitive inhibitor. CID 2011756 was the most potent of the inhibitors with a cellular EC50 of 10?0.7 ?M (n = 3), an EC50 value comparable to that of our previously described benzoxoloazepinolone. In vitro, it can be used by 70?M in LNCaP prostate cancer cells [1].

References

[1] Sharlow ER, Mustata Wilson G, Close D, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. . 2011;, 6(10):e25134.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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