Cidofovir Inhibitor CAS No. 113852-37-2

Cat. No.	Name	Size	Price	Add Cart
KI0805	Cidofovir	25 mg	$154
KI0805	Cidofovir	100 mg	$432

Chemical Characteristic

Product Name	Cidofovir
Synonyms	Vistide
CAS No.	113852-37-2
Molecular Weight	279.19
Formula	C₈H₁₄N₃O₆P
Chemical Name	[1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
Smiles	C(P(=O)(O)O)OC(Cn1c(=O)nc(cc1)N)CO
Chemical Structure

Biological activities

Cidofovir is a cytidine nucleotide analogue. Cidofovir has in vitro activity against a broad spectrum of herpesviruses, including CMV, HSV-1 and -2, VZV, EBV, HHV-6 and KSHV (HHV-8), as well as against adenovirus, human papillomavirus (HPV), polyoma-viruses, and human poxviruse. Cidofovir is used as an intravenous treatment for human cytomegalovirus (HCMV) retinitis. Cidofovir inhibits herpesviruses VZV, EBM, HHV-8 (KSHV) with IC50 of 0.79, 0.03 and 0.5µM, respectively. Cidofovir suppresses herpesvirus replication by selective inhibition of viral DNA synthesis. Cidofovir acts as both a potent inhibitor and an alternate substrate for viral DNA polymerase, in competition with the natural substrate deoxycytidine triphosphate (dCTP) after intracellular phosphorylation to the diphosphate metabolite. Cidofovir also has great antiviral activity against poxviruses. Cidofovir inhibits Variola Vero, Variola BSC, Cowpox Vero, Cowpox BSC, Camelpox Vero, Camelpox BSC with IC50 of 6.0, 8.0, 62.0, 31.0, 22.0, 28.0µM, respectively. Besides, cidofovir in combination with either ganciclovir or foscarnet demonstrates synergistic inhibition of HCMV replication. ^[1] In vivo, cidofovir has shown high efficacy in protecting mice from a lethal respiratory infection with either vaccinia or cowpox. Cidofovir is also effective in the treatment of vaccinia virus infection in severe combined immune deficiency mice.^[2]

References

[1] Safrin S, et al. Clinical uses of cidofovir. Rev Med Virol. 1997, 7 (3): 145-156. [2] Erik DC, et al. Cidofovir in the treatment of poxvirus infections. Antiviral Res. 2002, 55(1): 1-33.

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