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Cat. No. Name Size Price Add Cart
KI1007Cilnidipine20 mg$155.2
Cilnidipine50 mg$272

Chemical Characteristic

Product NameCilnidipine
SynonymsFRC-8653
CAS No.132203-70-4
Molecular Weight 492.52
FormulaC27H28N2O7
Chemical Name(+/-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
SmilesC1(=C(C(C(=C(N1)C)C(=O)OC/C=C/c1ccccc1)c1cc(ccc1)[N](=O)O)C(=O)OCCOC)C
Chemical Structure

Biological activities

Cilnidipine is a novel 1, 4-dihy-dropyridine (DHP) type of organic Ca2+ channel blocker that has slow-onset and long-lasting hypotensive effect. Cilnidipine reduces blood pressure by blocking L-type Ca2+ channels in vascular smooth muscle. And cilnidipine depresses sympathetic nerve tonus by modulating the N-type Ca2+ channel in the endings of the sympathetic peripheral nervous system. Cilnidipine inhibits the L-type and N-type Ca2+ channels with IC50 of 100 and 100 nM, respectively. [1] Cilnidipine inhibits KCl-induced vasoconstriction and also inhibits [3H]-noradrenaline (NA) release evoked by electrical stimulation in the rat aorta.[2] Cilnidipine can cause an inhibition of the pressor response induced by acute cold stress in addition to its hypotensive effect.[3]

Protocols

Cilnidipine is dissolved in DMSO at 10 mM as stock solutions. [1]

References

[1] Fujii S, et al. Effect of cilnidipine, a novel dihydropyridine Ca2+-channel antagonist, on N-type Ca2+ channel in rat dorsal root ganglion neurons. J Pharmcol Exp Ther. 1997, 280 (3): 1184-1191.
[2] Uneyama H, et al. Blockade of N-type Ca2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurons. British Journal of Pharmacology. 1997, 122 (1): 37-42.
[3] Minami J, et al. Effects of cilnidipine, a novel dihydropyridine calcium antagonist, on autonomic function, ambulatory blood pressure and heart rate in patients with essential hypertension. Br J Clin Pharmacol. 2000, 50 (6): 615-620.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

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