Cisplatin Inhibitor CAS No. 15663-27-1

Cat. No.	Name	Size	Price	Add Cart
KI1274	Cisplatin	50 mg	$154

Chemical Characteristic

Product Name	Cisplatin
Synonyms	Cisplatinum,cis-diamminedichloroplatinum(II), CDDP, Platin
CAS No.	15663-27-1
Molecular Weight	300.05
Formula	Cl₂H₆N₂Pt
Chemical Name	Platinum, diamminedichloro-, (SP-4-2)-
Smiles	[Pt](Cl)(Cl)(N)N
Chemical Structure

Biological activities

Cisplatin is a chemotherapy drug. Cisplatinis used in the treatment of various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors.^[1]Cisplatin induces apoptosis mediated by the intrinsic pathway in colon cancer cells.^[2]Cisplatininhibits the PA-1 cell line with an IC50 of 0.6 µM.^[3]Treatment of cisplatin for 24 or 48 hours increases the cdk2 activity.^[4]Cisplatin exerts their cytotoxic effect by inducing DNA damage and activating programmed cell death (apoptosis).Cisplatinincreases the amount of p73 protein in the cell including mouse embryo fibroblasts.^[5]A standard cisplatin treatment induces approximately 50% increase in the amount of p53 in both parental and σ-KO HCT116 cells.^[6]Cisplatin prolongs the survival of animals with 9LpCEP4p53 cells at the 4 mg/kg weekly for 7 weeks.^[7]

Protocols

In vitro: Cisplatinis dissolved at 1 mg/ml in phosphate-buffered saline (PBS), pH 7.4, and stored at room temperature in the dark.^[6]

References

[1]Einhorn LH. Treatment of testicular cancer: a new and improved model.J ClinOncol. 1990, 8(11), 1777-17781. [2] Pruefer FG, et al. Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells.J Chemother. 2008, 20(3), 348-354. [3]Cagnoli M, et al. Synthesis and biological activity of gold and tin compounds in ovarian cancer cells.Anticancer Drugs. 1998,(7), 603-610. [4]Price PM, et al. Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. J Am SocNephrol. 2006, 17(9), 2434-42. [5]Gong JG, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage.Nature. 1999, 399(6738), 806-809. [6] Han Z, et al. 14-3-3sigma-dependent resistance to cisplatin. Anticancer Res. 2009, 29(6), 2009-2014. [7]Dorigo O, et al. Sensitization of rat glioblastomamultiforme to cisplatin in vivo following restoration of wild-type p53 function.J Neurosurg. 1998, 88(3), 535-540.

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