Cat. No. Name Size Price Add Cart
KI1379Citalopram Hydrobromide10 mg$250
Citalopram Hydrobromide50 mg$1120

Chemical Characteristic

Product NameCitalopram Hydrobromide
CAS No.59729-32-7
Molecular Weight 405.31
FormulaC20H22BrFN2O
Chemical Name(R)-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide
SmilesC1(OCc2cc(ccc12)C#N)(c1ccc(cc1)F)CCCN(C)C Br
Chemical Structure

Biological activities

Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) that widely used as antidepressants. Citalopram hydrobromide blocks the transport of [-]-2, 5-dimethoxy-4-methylamphetamine (DOM) by the serotonin transporter and acts via the 5-HT1A and 5-HT2C receptors. In equilibrium saturation studies of [3H] citalopram hydrobromide binding, the data indicate a single population of binding sites, with a KD of 0.77 nM (pKD=9.11) and a Bmax equal to 372.0 fmol/mg. Citalopram hydrobromide potentiates the stimulus effects of the phenethylamine hallucinogen DOM in the rat. [1] Citalopram hydrobromide (10 mg/kg) increases the abnormally low level of social interaction behavior in the flinders sensitive line rats. [2] Low dose citalopram hydrobromide reverses both scopolamine- and THC-induced impairment of spatial memory, suppresses ECS-induced immobilization reversed the THC-induced decrease of acetylcholine (ACh) release in the dorsal hippocampus in vivo microdialysis, and enhances tremors induced by oxotremorine. Citalopram hydrobromide has been widely used in several disorders related to serotonergic dysfunction, including depression, anxiety, panic disorders, obsessive-compulsive disorder and premenstrual dysphoria.[3]

Protocols

Citalopram hydrobromide is dissolved in distilled water in vitro assay. [2]

References

[1] Eckler JR, et al. A 5-HT (2C) receptor-mediated interaction between 2, 5-dimethoxy-4-methylamphetamine and citalopram in the rat. Pharmacol Biochem Behav. 2004, 79(1): 25-30.
[2] Overstreet DH, et al. Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression. Eur J Pharmacol. 2004, 492(2-3): 195-201.
[3] Egashira N, et al. Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization. Pharmacol Biochem Behav. 2006, 83(1):161-167.

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