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Cat. No. Name Size Price Add Cart
KI1342Clopidogrel bisulfate100 mg$120

Chemical Characteristic

Product NameClopidogrel bisulfate
SynonymsPlavix
CAS No.120202-66-6
Molecular Weight 419.9
FormulaC16H18ClNO6S2
Chemical NameThieno[3,2-c]pyridine-5(4H)-acetic acid, ?-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (?S)-, sulfate
SmilesC1c2c(CCN1C(C(=O)OC)c1c(cccc1)Cl)scc2 OS(=O)(=O)O
Chemical Structure

Biological activities

Clopidogrel bisulfate is an ADP receptor antagonist that displays a selective binding on the platelet surface to adenylate cyclase-coupled ADP receptors. Clopidogrel bisulfate is a potent antiplatelet and antithrombotic drug that is used for the prevention of atherothrombotic complications following acute coronary syndromes (ACS) or percutaneous coronary interventions (PCIs). Clopidogrel bisulfate is an inactive prodrug and requires hepatic biotransformation catalyzed by cytochrome P450 isozymes, mainly 3A4, to display anti-aggregation property.[1] Clopidogrel bisulfate in combination with aspirin is the current ??old standard??for reducing cardiovascular events, providing a synergistic platelet inhibition through different platelet activation pathways. Besides, clopidogrel bisulfate induces irreversible modifications of the platelet ADP receptor PY12 mediating inhibition of stimulated adenylyl cyclase activity by ADP. [2] In addition, proton pump inhibitors (PPIs) diminish clopidogrel bisulfate efficacy via CYP2C19 competitive inhibition. [3]

Protocols

Stock solutions of clopidogrel bisulfate is prepared in methanol at 2 mM, and kept in the dark at 4°C. [4]

References

[1] Mullangi R, et al. Clopidogrel: review of bioanalytical methods, pharmacokinetics /pharmacodynamics, and update on recent trends in drug-drug interaction studies. Biomed Chromatogr. 2009, 23 (1): 26-41.
[2] Rossini R, et al. Clopidogrel: Clopidogrel Bisulfate: A Review of its Use in the Management of Acute Coronary Syndrome. The Asia-pacific Journal of cardiovascular medicine. 2009, 1 (1): 1-9.
[3] Lima JP, et al. The potential interaction between clopidogrel and proton pump inhibitors: a systematic review. BMC Med. 2010, 8: 81.
[4] Serra H, et al. Simultaneous determination of clopidogrel and its carboxylic acid metabolite by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci. 2010, 878 (19): 1480-1486.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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