Clotrimazole Inhibitor CAS No. 23593-75-1

Cat. No.	Name	Size	Price	Add Cart
KI0984	Clotrimazole	100 mg	$90

Chemical Characteristic

Product Name	Clotrimazole
Synonyms	Lotrimin, Bay b 5097
CAS No.	23593-75-1
Molecular Weight	344.837
Formula	C₂₂H₁₇ClN₂
Chemical Name	1-?[(2-?chlorophenyl)?diphenylmethyl]?-1H-?imidazole
Smiles	C(c1ncc[nH]1)(c1ccccc1)(c1ccccc1)c1c(cccc1)Cl
Chemical Structure

Biological activities

Clotrimazole is a synthetic antifungal drug with in vitro activity against Candida spp., Torulopsis glabrata, and Saccharomyces spp.. The MIC of clotrimazole for the majority of Candida spp. is 1.56 µg/mL.^[1] In vitro, clotrimazole effectively and rapidly inhibits parasite growth in five different strains of P. falciparum. Clotrimazole inhibits parasite growth with IC50 values between 0.2 and 1.1 µM, irrespective of the chloroquine sensitivity of the strain. Clotrimazole alters P. falciparum morphology and interferes with parasite development and replication. ^[2] Clotrimazole is a potent and specific inhibitor of the Ca²⁺-activated K⁺ channel of sickle erythrocytes. Clotrimazole blocks almost completely Ca²⁺-activated K⁺ transport in homozygous hemoglobin S cells, with IC50 of 29 nM in isotonic 20 mM salt solution and 51 nM in normal saline. Clotrimazole markedly reduces K⁺ permeability with IC50 of 33 and 208 nM, in low ionic strength conditions and in normal saline, respectively. Oral administration of clotrimazole prevents red cell dehydration with sickle cell anemia.^[3]

References

[1] Burgess MA, et al. Clotrimazole (Bay b 5097): in vitro and clinical pharmacological studies. Antimicrob Agents Chemother. 1972, 2(6): 423-246. [2] Tiffert T, et al. Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum. Proc Natl Acad Sci U S A. 2000, 97(1): 331-336. [3] Brugnara C, et al. Inhibition of Ca(2+)-dependent K⁺ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest. 1993, 92(1): 520-526.

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