CP945598 Inhibitor CAS No. 919516-56-6

Cat. No.	Name	Size	Price	Add Cart
KI3674	CP945598	10 mg	$336

Chemical Characteristic

Product Name	CP945598
Synonyms	Otenabant
CAS No.	919516-56-6
Molecular Weight	546.89
Formula	C₂₅H₂₅Cl₂N₇O
Smiles	C1C(CCN(C1)c1ncnc2c1nc(n2c1ccc(cc1)Cl)c1ccccc1Cl)(C(=O)N)NCC
Chemical Structure

Biological activities

Otenabant (CP945598) is a recently discovered selective, high affinity, competitive CB1 receptor antagonist. ^[1] Otenabant is progressed into Phase 3 human clinical trials as an oral agent for the treatment of obesity. It reduces acute food intake in rodents, decreases food intake and body weight in obese Beagle dogs and humans, and acutely stimulates energy expenditure in rats ^[2].In vitro, the IC50 of otenabant to CB1 is 0.7 nM(Ki for binding)/0.2 nM (Ki for function). In vivo, it can be used by 10 mg/kg in obese mice ^[3].

References

[1]. Hadcock JR, Griffith DA, Iredale PA, et al. Scott In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochemical and Biophysical Research Communications. 2010, 394:366-371. [2]. Zhuang Miao, Scott DO, Griffith DA, et al. Excretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and Dogs. Drug Metab. Dispos. 2011, 39: 568-578. [3]. Griffith DA, Hadcock JR, Black SC, et al. Discovery of 1-[9-(4-chlorophenyl) -8-(2-chlorophenyl)- 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. JMedChem. 2009, 52(2):234-237.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com