CUDC-907 Inhibitor CAS No. 1339928-25-4

Cat. No.	Name	Size	Price
KI0518	CUDC-907	5 mg	$432
	CUDC-907	10 mg	$592
	CUDC-907	50 mg	$1712
	CUDC-907	200 mg	$3952

Chemical Characteristic

Product Name	CUDC-907
CAS No.	1339928-25-4
Molecular Weight	508.55
Formula	C₂₃H₂₄N₈O₄S
Chemical Name	N-Hydroxy-2-[[[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl](methyl)amino]pyrimidine-5-carboxamide
Smiles	c1(ncc(cn1)C(=O)NO)N(C)Cc1cc2nc(nc(c2s1)N1CCOCC1)c1cnc(cc1)OC
Chemical Structure

Biological activities

CUDC-907 is a potent inhibitor of both HDAC and PI3K. CUDC-907 inhibits class I PI3K kinases (PI3Kα, PI3Kβ and PI3Kδ) with IC50 of 19, 54 and 39 nM, respectively. CUDC-907 durably inhibits the PI3K-AKT-mTOR pathway and compensatory signaling molecules such as RAF, MEK, MAPK, and STAT-3, as well as upstream receptor tyrosine kinases. CUDC-907 shows greater growth inhibition and proapoptotic activity than single-target PI3K or HDAC inhibitors in both cultured and implanted cancer cells.^[1] CUDC-907 inhibits PI3Kα H1047R and PI3Kα E554655K with IC50 of 73 and 62 nM, respectively. CUDC-907 also inhibits HDAC subtypes (HDAC1, HDAC2, HDAC3, HDAC6, HDAC10 and HDAC11) with IC50 of 1.7, 5.0, 1.8, 27, 2.8 and 5.4 nM, respectively. CUDC-907 potently inhibits proliferation of hematological cancer cell lines (B cell lymphoma, Myeloma). CUDC-907 is able to enhance antitumor activity when combined with standard of care agents in multiple myeloma and B cell lymphoma xenograft models. ^[2]

Protocols

For in vivo studies, CUDC-907 is formulated in 30% Captisol. ^[1]

References

[1] Qian C, et al. Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling. Clin Cancer Res. 2012, 18(15): 4104-4113. [2] Bao R, et al. Antitumor Activity of CUDC-907, a dual PI3K and HDAC inhibitor in hematological cancer models. AACR Poster. 2012 # 3744.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com