Curcumin Inhibitor CAS No. 458-37-7

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KI0926	Curcumin	1 g	$38

Chemical Characteristic

Product Name	Curcumin
Synonyms	Diferuloylmethane
CAS No.	458-37-7
Molecular Weight	368.38
Formula	C₂₁H₂₀O₆
Chemical Structure

Biological activities

Curcumin is a cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor. The IC50 of curcumin is 10 µM against InsP_{3-induced Ca²⁺ release (IICR). Curcumin reduces agonist (ATP)-stimulated Ca²⁺ mobilization from intact HL-60 cells.^[1] Curcumin is also a potent inhibitor for AP-1 and NF-kappaB activation. Curcumin inhibits JNK activation by various agonists including PMA plus ionomycin, anisomycin, UV-C, gamma radiation, TNF-alpha, and sodium orthovanadate.^[2] Curcumin up-regulates caspase family proteins. Curcumin down-regulates anti-apoptotic genes (Bcl-2 and Bcl-X(L)).^[3] Curcumin inhibits animal and human cancers, suggesting that it may serve as a chemopreventive agent.^[4] Curcumin induces apoptosis through mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades.^[5] Curcumin inhibits pAKT, pS6, p-4EBP1, pSTAT3, and pERK1/2 in SRB12-p9 cells.^[6] Curcumin is actively transported into bile.^[7]}

Protocols

In vivo Curcumin is dissolved in 0.1 M NaOH (20 mg/mL).^[7]

References

[1] Dyer JL, et al. Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor. Cell Calcium. 2002, 31(1): 45-52. 閵嗏偓閵嗏偓 [2] Chen YR, et al. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene. 1998, 17(2): 173-178. 閵嗏偓閵嗏偓 [3] Shehzad A et al. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 2010, 343(9): 489-499. 閵嗏偓閵嗏偓 [4] Shehzad A, et al. Molecular mechanisms of curcumin action: Signal transduction. Biofactors. 2013. 閵嗏偓閵嗏偓 [5] Shehzad A, et al. Curcumin in inflammatory diseases. Biofactors. 2012 閵嗏偓閵嗏偓 [6] Sonavane K, et al. Topical curcumin-based cream is equivalent to dietary curcumin in a skin cancer model. J Skin Cancer. 2012. 閵嗏偓閵嗏偓 [7] Wahlstr?m B, et al. A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol (Copenh). 1978, 43(2): 86-92. 閵嗏偓閵嗏偓

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