Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI1391CX-49452 mg$272
CX-49455 mg$512
CX-494550 mg$2672
CX-4945100 mg$3792

Chemical Characteristic

Product NameCX-4945
SynonymsSilmitasertib
CAS No.1009820-21-6
Molecular Weight 349.77
FormulaC19H12ClN3O2
Chemical Name5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid
Smilesc1(nc2c(c3cnccc13)ccc(c2)C(=O)O)Nc1cc(ccc1)Cl
Chemical Structure

Biological activities

CX-4945 is a potent, selective, and ATP-competitive inhibitor of CK2. CX-4945 inhibits isoforms of the CK2 catalytic subunits CK2α and CK2α??with an IC50 of 1 nM, and inhibits recombinant CK2 with an IC50 of 2 nM.[1] CX-4945 also inhibits endogenous CK2 activity in Jurkat cells with an IC50 of 100 nM.[2] CX-4945 effectively reduces CK2 enzymatic activity and exhibits a broad range of anti-proliferative activity in cancer cell lines, and the breast cancer cell lines display the widest range of sensitivity. In models of angiogenesis, CX-4945 inhibits human umbilical vein endothelial cell (HUVEC) migration, tube formation, and blocks CK2- dependent hypoxia-induced HIF-1945; transcription in cancer cells with IC50 of 5.5, 2.0 and 4.0 µM, respectively.[1] CX-4945 exhibits a dose-dependent antitumor activity in a xenograft model of PC3 prostate cancer model and is well tolerated.[3] CX-4945 (75 mg/kg) demonstrates robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 in murine xenograft models.[1]

Protocols

CX-4945 is prepared in DMSO in 5 mM and stored at -70°C.[1]

References

[1] Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010, 70 (24): 10288-10298.
[2] Anderes K, et al. Discovery and characterization of CX-4945, a selective orally bioavailable small molecule inhibitor of protein kinase CK2: Phase 1 initiated.
[3] Pierre F, et al. Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer. Mol Cell Biochem. 2011, 356 (1-2): 37-43.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook