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KI2562CYM5026010 mg$351
CYM5026050 mg$1547

Chemical Characteristic

Product NameCYM50260
SynonymsN/A
CAS No.1355026-60-6
Molecular Weight 350.6
FormulaC14H11Cl3FNO2
Chemical Name?2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine
Smilesc1(c(ccc(n1)CF)OCCOc1c(cc(cc1)Cl)Cl)Cl
Chemical Structure

Biological activities

CYM50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) inhibitor. CYM50260 inhibits S1P4 with an EC50 of 45 nM. Meanwhile, CYM50260 displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM. Furthermore, CYM50260 is found 3.5-fold more potent than cycloalkanes and is equipotent to the dibromine analog.[1]

References

[1]Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg Med Chem Lett. 2012, 22 (1): 537-542.

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