Cat. No. Name Size Price Add Cart
KI2568CZC2483210 mg$384
CZC2483250 mg$1310

Chemical Characteristic

Product NameCZC24832
SynonymsN/A
CAS No.1159824-67-5
Molecular Weight 364.4
FormulaC15H17FN6O2S
Chemical Name?5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide
Smilesc1c(cc(cn1)c1cc(c2n(c1)nc(n2)N)F)S(=O)(=O)NC(C)(C)C
Chemical Structure

Biological activities

CZC24832 is a highly selective and potent ATP-competitive PI3Kγ inhibitor. In vivo, CZC24832 shows anti-inflammatory effects in a collagen-induced arthritis model. Meanwhile, CZC24832 suppresses inflammatory responses in mouse models in a dose-dependent manner.[1]

Protocols

In vivo: CZC24832 is dissolved in DMSO.[1]

References

[1] Blunt MD, et al. Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities. Front Immunol. 2012, 3: 226.

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