Daidzein Inhibitor CAS No. 486-66-8

Cat. No.	Name	Size	Price	Add Cart
KI1021	Daidzein	50 mg	$154

Chemical Characteristic

Product Name	Daidzein
CAS No.	486-66-8
Molecular Weight	254.23
Formula	C₁₅H₁₀O₄
Chemical Name	7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
Smiles	c1c(c(=O)c2c(o1)cc(cc2)O)c1ccc(cc1)O
Chemical Structure

Biological activities

Daidzein is a major isoflavone in soybean foods and is antioxidant and antiestrogen. Daidzein inhibits the production of inositol phosphates of 3T3 cell with an IC50 of 8 µM. ^[1] Daidzein inhibits transactivation of rat ERα and ERβ in HepG2 human hepatoma cells with EC50 of 390 and 87 nM. ^[2] Daidzein inhibits the growth of both estrogen receptor-positive (MCF-7) and negative (MDA-468) human breast cancer cell lines with IC50 of 24 and 79 µM, respectively. ^[3] Daidzein is able to relax rat mesenteric arteries endothelium-independently in vitro. Daidzein inhibits calcium uptake via L-type calcium channels at least in rat pituarity cells. ^[4] Daidzein prevents the ovariectomy-induced BMD reduction at both the cancellous and cortical sites by suppressing the bone turnover increase. Daidzein consumption also results in the preservation of cancellous bone area in the distal femur metaphysis. ^[5]

Protocols

Daidzein is dissolved in ethanol. ^[4]

References

[1] Xu X, et al. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr. 1994, 124(6): 825-832. [2] Casanova M, et al. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro. Toxicol Sci. 1999, 51(2): 236-244. [3] Zhang Y, et al. Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. J Nutr. 1999, 129(2): 399-405. [4] Nevala R, et al. Calcium-sensitive potassium channel inhibitors antagonize genistein- and daidzein-induced arterial relaxation in vitro. Life Sci. 2001, 69(12): 1407-1417. [5] Picherit C, et al. Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J Nutr. 2000, 130(7): 1675-1681.

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